Hormonal
PTH (1-34)
The active fragment of parathyroid hormone
Reference entry · not stocked
69 more in HormonalIdentity
- Class
- Hormonal
- Molecular weight
- 4118 Da
- Residues
- 34
- Heavy atoms
- 289
- Reference slug
- pth-1-34
These are published properties of the molecule, given for identification. Values we cannot confirm are omitted rather than estimated. What these terms mean.
What this compound is
Thirty-four residues, the shortest fragment of parathyroid hormone that retains full activity. The full hormone is 84 residues, so this is the part that matters, drawn as the helix it forms.
Sequence
| 1 | SVSEIQLMHN LGKHLNSMER VEWLRKKLQD VHNF |
|---|
- Three-letter code
- Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe
The one-letter code gives the amino-acid backbone. Terminal modifications, where a compound carries them, are accounted for in the molecular weight above but are not visible in the letters.
Residue composition
Counted directly from the sequence above. PTH (1-34) is built from 15 of the twenty standard amino acids across 34 positions.
By residue
| Residue | Code | Count | Share |
|---|---|---|---|
| Leucine | L · Leu | 5 | 14.7% |
| Glutamic acid | E · Glu | 3 | 8.8% |
| Histidine | H · His | 3 | 8.8% |
| Lysine | K · Lys | 3 | 8.8% |
| Asparagine | N · Asn | 3 | 8.8% |
| Serine | S · Ser | 3 | 8.8% |
| Valine | V · Val | 3 | 8.8% |
| Methionine | M · Met | 2 | 5.9% |
| Glutamine | Q · Gln | 2 | 5.9% |
| Arginine | R · Arg | 2 | 5.9% |
| Aspartic acid | D · Asp | 1 | 2.9% |
| Phenylalanine | F · Phe | 1 | 2.9% |
| Glycine | G · Gly | 1 | 2.9% |
| Isoleucine | I · Ile | 1 | 2.9% |
| Tryptophan | W · Trp | 1 | 2.9% |
By side-chain class
Nonpolar, aliphatic
12 · 35.3%
G I L M V
Aromatic
2 · 5.9%
F W
Polar, uncharged
8 · 23.5%
N Q S
Positively charged
8 · 23.5%
H K R
Negatively charged
4 · 11.8%
D E
Side-chain classes follow the standard grouping of the twenty proteinogenic amino acids. Composition is arithmetic over the published sequence and says nothing about how the molecule behaves.
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Reference entry
This is a reference entry. Sequence, residue count, molecular weight and atom count are published properties of the molecule, given for identification. Nothing on this page describes an application, benefit, dose, route or outcome, and nothing here should be read as an offer to supply or as guidance for use in a person or an animal. Materials sold by PepXtide are for laboratory research use only, are not for human or animal consumption, and have not been evaluated by the FDA.