Identity
- Class
- Bioregulators
- Molecular weight
- 390 Da
- Residues
- 4
- Heavy atoms
- 47
- Reference slug
- epitalon
These are published properties of the molecule, given for identification. Values we cannot confirm are omitted rather than estimated. What these terms mean.
What this compound is
Four residues, two of them acidic. One of the shortest peptides in the library, small enough that every hydrogen is drawn. Studied in work on the pineal gland.
Sequence
| 1 | AEDG |
|---|
- Three-letter code
- Ala-Glu-Asp-Gly
The one-letter code gives the amino-acid backbone. Terminal modifications, where a compound carries them, are accounted for in the molecular weight above but are not visible in the letters.
Residue composition
Counted directly from the sequence above. Epitalon is built from 4 of the twenty standard amino acids across 4 positions.
By residue
| Residue | Code | Count | Share |
|---|---|---|---|
| Alanine | A · Ala | 1 | 25% |
| Aspartic acid | D · Asp | 1 | 25% |
| Glutamic acid | E · Glu | 1 | 25% |
| Glycine | G · Gly | 1 | 25% |
By side-chain class
Nonpolar, aliphatic
2 · 50%
A G
Negatively charged
2 · 50%
D E
Side-chain classes follow the standard grouping of the twenty proteinogenic amino acids. Composition is arithmetic over the published sequence and says nothing about how the molecule behaves.
Primary literature
5 peer-reviewed papers indexed in PubMed that name this compound in the title. Each record was checked against the database for title, journal and year rather than written from memory.
Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties
Int J Mol Sci2025PMID 40141333
[Peptide Ala-Glu-Asp-Gly and interferon gamma: their role in immune response during aging]
Adv Gerontol2012PMID 23289226
The Antioxidant Tetrapeptide Epitalon Enhances Delayed Wound Healing in an in Vitro Model of Diabetic Retinopathy
Stem Cell Rev Rep2025PMID 40493162
Epitalon protects against post-ovulatory aging-related damage of mouse oocytes in vitro
Aging (Albany NY)2022PMID 35413689
Effects of intranasal administration of epitalon on neuron activity in the rat neocortex
Neurosci Behav Physiol2007PMID 17955380
Citations are listed so the underlying research can be read directly. They describe laboratory and preclinical work on the molecule. They are not evidence of a benefit, and nothing here is an application, dose, route or outcome.
Reference databases
PubChem
Compound record: Epitalon
Resolved from the compound name
PubMed
Indexed literature
Live search for Epitalon
Links resolved against the live databases on 2026-08-29.
Others in Bioregulators
Bronchogen
4 residues · 446 Da
Four residues sharing the acidic core common to this family, with a leucine at the end.
Reference entry
Cardiogen
4 residues · 489 Da
Four residues. The same core again, closing on an arginine rather than a leucine or a proline.
Reference entry
Chonluten
3 residues · 319 Da
Three residues, two of them acidic. One of the smallest structures here.
Reference entry
Cortagen
4 residues · 430 Da
Four residues, the same acidic core as Epitalon with a proline in place of the glycine. Comparin…
Reference entry
Crystagen
3 residues · 359 Da
Three residues ending in proline.
Reference entry
Ovagen
3 residues · 375 Da
Three residues, two acidic and one aliphatic.
Reference entry
This is a reference entry. Sequence, residue count, molecular weight and atom count are published properties of the molecule, given for identification. Nothing on this page describes an application, benefit, dose, route or outcome, and nothing here should be read as an offer to supply or as guidance for use in a person or an animal. Materials sold by PepXtide are for laboratory research use only, are not for human or animal consumption, and have not been evaluated by the FDA.