Identity
- Class
- Metabolic
- Molecular weight
- 4187 Da
- Residues
- 39
- Heavy atoms
- 295
- Reference slug
- exenatide
These are published properties of the molecule, given for identification. Values we cannot confirm are omitted rather than estimated. What these terms mean.
What this compound is
Thirty-nine residues ending in an amide. Originally isolated from the saliva of the Gila monster, and the reason it resists the enzyme that clears the human hormone is the glycine at position two.
Sequence
| 1 | HGEGTFTSDL SKQMEEEAVR LFIEWLKNGG PSSGAPPPS |
|---|
- Three-letter code
- His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser
The one-letter code gives the amino-acid backbone. Terminal modifications, where a compound carries them, are accounted for in the molecular weight above but are not visible in the letters.
Residue composition
Counted directly from the sequence above. Exenatide is built from 18 of the twenty standard amino acids across 39 positions.
By residue
| Residue | Code | Count | Share |
|---|---|---|---|
| Glutamic acid | E · Glu | 5 | 12.8% |
| Glycine | G · Gly | 5 | 12.8% |
| Serine | S · Ser | 5 | 12.8% |
| Proline | P · Pro | 4 | 10.3% |
| Leucine | L · Leu | 3 | 7.7% |
| Alanine | A · Ala | 2 | 5.1% |
| Phenylalanine | F · Phe | 2 | 5.1% |
| Lysine | K · Lys | 2 | 5.1% |
| Threonine | T · Thr | 2 | 5.1% |
| Aspartic acid | D · Asp | 1 | 2.6% |
| Histidine | H · His | 1 | 2.6% |
| Isoleucine | I · Ile | 1 | 2.6% |
| Methionine | M · Met | 1 | 2.6% |
| Asparagine | N · Asn | 1 | 2.6% |
| Glutamine | Q · Gln | 1 | 2.6% |
| Arginine | R · Arg | 1 | 2.6% |
| Valine | V · Val | 1 | 2.6% |
| Tryptophan | W · Trp | 1 | 2.6% |
By side-chain class
Nonpolar, aliphatic
17 · 43.6%
A G I L M P V
Aromatic
3 · 7.7%
F W
Polar, uncharged
9 · 23.1%
N Q S T
Positively charged
4 · 10.3%
H K R
Negatively charged
6 · 15.4%
D E
Side-chain classes follow the standard grouping of the twenty proteinogenic amino acids. Composition is arithmetic over the published sequence and says nothing about how the molecule behaves.
Others in Metabolic
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In our catalogue
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30 residues · 3298 Da
Thirty residues, the fragment of GLP-1 that is actually active. Every long-acting analogue of it…
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GLP-2
33 residues · 3766 Da
Thirty-three residues, cut from the same precursor protein as GLP-1 but acting on the gut lining…
Reference entry
This is a reference entry. Sequence, residue count, molecular weight and atom count are published properties of the molecule, given for identification. Nothing on this page describes an application, benefit, dose, route or outcome, and nothing here should be read as an offer to supply or as guidance for use in a person or an animal. Materials sold by PepXtide are for laboratory research use only, are not for human or animal consumption, and have not been evaluated by the FDA.