Research use only. This compound is supplied for in-vitro laboratory research by qualified researchers. It is not for human or veterinary consumption and has not been evaluated by the FDA.
Neuro Research
N-Acetyl Semax Amidate
Certificate pending · 30mg
30mg$100.00each
$3.33/mg
N-Acetyl Semax Amidate is the heptapeptide Semax with an acetyl group on the N-terminal methionine and a primary amide on the C-terminal proline. Its deposited structure is PubChem CID 172638603.
Base Semax is Met-Glu-His-Phe-Pro-Gly-Pro. Registries describe it as corticotropin residues 4 to 7 extended with Pro-Gly-Pro, while much of the literature calls it an analogue of corticotropin 4 to 10; both describe the same molecule, and the registry description is the literal one. Checked against UniProt P01189, corticotropin residues 4 to 7 are indeed Met-Glu-His-Phe.
Both modifications are read directly off the deposited structure rather than inferred. The acetyl is on the alpha-amino group of Met1, the amide is on Pro7, and the glutamate side-chain carboxyl at position 4 stays free - the amidation is C-terminal only, not a side-chain amide. The composition change relative to base Semax is the addition of C2H3N, which is what the registered masses show.
A one-dalton neighbour is the impurity that matters here and it is easy to mislabel. The corresponding free acid, acetyl-MEHFPGP-OH, is registered separately as PubChem CID 172107353 with formula C39H53N9O11S and a mass near 856.0. The two are trivially swapped on a specification table and are cleanly separated by accurate-mass measurement, at 854.375 against 855.359 monoisotopic. Their chromatographic behaviour differs too: removing both terminal charges makes the amidate measurably less hydrophilic than base Semax and it retains longer on a C18 column.
No CAS number is printed. One circulates for this compound, but every depositor carrying it on PubChem is a commercial supplier, and it has no corroboration from a regulator, from the patent literature or from a publication. FDA GSRS holds no record of this compound at all. Base Semax does have a registry-backed number, 80714-61-0, but it describes the unmodified peptide.
The modifications exist for a documented reason. Shevchenko and colleagues reported in 2013 that when base Semax is digested by leucine aminopeptidase and by enzymes of nasal mucus, brain microsomal fraction and blood, the only detected metabolite was His-Phe-Pro-Gly-Pro - that is, the N-terminal Met-Glu is removed. The C-terminal Pro-Gly-Pro already resists that attack from the other end; acetylation closes the end the enzymes actually use.
The sequence has one phenylalanine and one histidine but no tryptophan and no tyrosine, so absorbance at 280 nm is not a valid concentration method. No molecular target is established: neither Semax nor this derivative appears in ChEMBL, and melanocortin-receptor activity is not merely unverified but structurally unsupported, because the His-Phe-Arg-Trp pharmacophore of corticotropin is incomplete here - the arginine and tryptophan are exactly what Pro-Gly-Pro replaced.
Certificate pending for the 30mg lot.The signed report will be published here as soon as the laboratory returns it.
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Compound information
- Type
- Neuro Research
- Molecular formula
- C39H54N10O10S
- Molecular weight
- 855.0 g/mol
- Sequence
- Ac-Met-Glu-His-Phe-Pro-Gly-Pro-NH2 (acetyl-MEHFPGP-amide)
- Form
- Lyophilized powder
- Vial strength
- 30mg
- Catalogue number
- PX-NASEMAX-30MG
- Purity
- Certificate pending for this strength
Identifiers are published properties of the molecule. Values we cannot confirm are omitted rather than estimated.
Research overview
Capped at both ends
Semax with both ends capped: an acetyl at the N-terminus and an amide at the C-terminus. Both are drawn, and the difference from the plain form is one oxygen.
- Residues
- 7
- Atoms
- 113
Primary literature
We have not compiled a reading list for this compound, and would rather show nothing than pad one out.
No public database record resolved for this compound under its catalogue name either. Rather than point you at a search that returns something else, this section stays empty.
PubMed, PubChem and ClinicalTrials.gov are independent scientific databases. A record or a published paper is not an endorsement of this product, and nothing indexed there describes an application, dose or outcome supported by PepXtide.
Storage & handling
Lyophilized
Store lyophilized at -20C, protected from light and moisture. Met1 is the liability and it is a real one: the thioether oxidises to the sulfoxide, sixteen daltons heavier, and on to the sulfone. Magri and colleagues, in the Journal of Inorganic Biochemistry in 2016, showed that this sulfur is chemically engaged rather than passive - it makes a weak apical contact with copper in the acetylated peptide's complex, whose formal redox potential is more positive than the free-amine peptide's and which, unlike the free-amine complex, reacts with ascorbic acid. So chelate trace metal, avoid peroxides and reducing sugars, and check for a plus-sixteen adduct on every release. There are two prolines, so cis and trans conformers broaden chromatographic peaks; that is the molecule, not an impurity..
Reconstituted
Refrigerate after reconstitution and use within the period appropriate to the material.
Safety & handling
Bench handling, not a dosing guide.
Intended use
Supplied strictly as a laboratory research material for in-vitro study by qualified researchers. Not for human or veterinary use, not for ingestion or injection, and not for any clinical or diagnostic application.
Personal protective equipment
Handle with gloves, eye protection and a laboratory coat. Weigh and transfer lyophilized powder in a ventilated enclosure to avoid generating an inhalable dust.
Reconstitution
Reconstitute against the diluent and volume appropriate to your protocol, adding solvent slowly down the vial wall rather than directly onto the pellet. Do not shake. This is a handling note, not a dosing guide.
Storage after opening
Once reconstituted, refrigerate and use within the period appropriate to the material. Avoid repeated freeze-thaw cycles, which degrade peptides faster than continuous storage at the listed temperature.
Disposal
Dispose of material and containers in accordance with your institution's chemical waste procedures and applicable local regulations.
Related compounds
Research notice
Supplied as a lyophilized powder for in-vitro laboratory research only. No statement on this page describes an application, benefit, dose, route or outcome. Descriptions are structural and mechanistic, and reference data such as CAS numbers and molecular formulas is published information about the compound itself, provided for identification. No measured result is shown for this strength because a certificate has not yet been published for its lot.