Metabolic
Pramlintide
Amylin analogue closed by a disulfide
Reference entry · not stocked
20 more in MetabolicIdentity
- Class
- Metabolic
- Molecular weight
- 3949 Da
- Residues
- 37
- Heavy atoms
- 277
- Reference slug
- pramlintide
These are published properties of the molecule, given for identification. Values we cannot confirm are omitted rather than estimated. What these terms mean.
What this compound is
Thirty-seven residues with cysteines at two and seven joined by a disulfide, closing a small ring at the N-terminal end while the rest of the chain runs free. Three prolines distinguish it from human amylin.
Sequence
| 1 | KCNTATCATQ RLANFLVHSS NNFGPILPPT NVGSNTY |
|---|
- Three-letter code
- Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-His-Ser-Ser-Asn-Asn-Phe-Gly-Pro-Ile-Leu-Pro-Pro-Thr-Asn-Val-Gly-Ser-Asn-Thr-Tyr
The one-letter code gives the amino-acid backbone. Terminal modifications, where a compound carries them, are accounted for in the molecular weight above but are not visible in the letters.
Residue composition
Counted directly from the sequence above. Pramlintide is built from 16 of the twenty standard amino acids across 37 positions.
By residue
| Residue | Code | Count | Share |
|---|---|---|---|
| Asparagine | N · Asn | 6 | 16.2% |
| Threonine | T · Thr | 5 | 13.5% |
| Alanine | A · Ala | 3 | 8.1% |
| Leucine | L · Leu | 3 | 8.1% |
| Proline | P · Pro | 3 | 8.1% |
| Serine | S · Ser | 3 | 8.1% |
| Cysteine | C · Cys | 2 | 5.4% |
| Phenylalanine | F · Phe | 2 | 5.4% |
| Glycine | G · Gly | 2 | 5.4% |
| Valine | V · Val | 2 | 5.4% |
| Histidine | H · His | 1 | 2.7% |
| Isoleucine | I · Ile | 1 | 2.7% |
| Lysine | K · Lys | 1 | 2.7% |
| Glutamine | Q · Gln | 1 | 2.7% |
| Arginine | R · Arg | 1 | 2.7% |
| Tyrosine | Y · Tyr | 1 | 2.7% |
By side-chain class
Nonpolar, aliphatic
14 · 37.8%
A G I L P V
Aromatic
3 · 8.1%
F Y
Polar, uncharged
17 · 45.9%
C N Q S T
Positively charged
3 · 8.1%
H K R
Side-chain classes follow the standard grouping of the twenty proteinogenic amino acids. Composition is arithmetic over the published sequence and says nothing about how the molecule behaves.
Others in Metabolic
PepX-3 RT
39 residues · 4076 Da
A 39-residue lipopeptide studied as a GLP-1 / GIP / glucagon receptor triple agonist. Two positi…
In our catalogue
Amylin
37 residues · 3903 Da
Thirty-seven residues with a small disulfide ring at the front. Pramlintide, also in this librar…
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17 residues · 2139 Da
Seventeen residues, four longer than apelin-13 at the front and strongly basic there. Both are h…
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Thirty-nine residues ending in an amide. Originally isolated from the saliva of the Gila monster…
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30 residues · 3298 Da
Thirty residues, the fragment of GLP-1 that is actually active. Every long-acting analogue of it…
Reference entry
This is a reference entry. Sequence, residue count, molecular weight and atom count are published properties of the molecule, given for identification. Nothing on this page describes an application, benefit, dose, route or outcome, and nothing here should be read as an offer to supply or as guidance for use in a person or an animal. Materials sold by PepXtide are for laboratory research use only, are not for human or animal consumption, and have not been evaluated by the FDA.