Metabolic
Teduglutide
GLP-2 with a single substitution
Reference entry · not stocked
20 more in MetabolicIdentity
- Class
- Metabolic
- Molecular weight
- 3752 Da
- Residues
- 33
- Heavy atoms
- 264
- Reference slug
- teduglutide
These are published properties of the molecule, given for identification. Values we cannot confirm are omitted rather than estimated. What these terms mean.
What this compound is
GLP-2 with the alanine at position two replaced by glycine. One residue, and it is the difference between something cleared in minutes and something that lasts hours, because that position is where the enzyme cuts.
Sequence
| 1 | HGDGSFSDEM NTILDNLAAR DFINWLIQTK ITD |
|---|
- Three-letter code
- His-Gly-Asp-Gly-Ser-Phe-Ser-Asp-Glu-Met-Asn-Thr-Ile-Leu-Asp-Asn-Leu-Ala-Ala-Arg-Asp-Phe-Ile-Asn-Trp-Leu-Ile-Gln-Thr-Lys-Ile-Thr-Asp
The one-letter code gives the amino-acid backbone. Terminal modifications, where a compound carries them, are accounted for in the molecular weight above but are not visible in the letters.
Residue composition
Counted directly from the sequence above. Teduglutide is built from 16 of the twenty standard amino acids across 33 positions.
By residue
| Residue | Code | Count | Share |
|---|---|---|---|
| Aspartic acid | D · Asp | 5 | 15.2% |
| Isoleucine | I · Ile | 4 | 12.1% |
| Leucine | L · Leu | 3 | 9.1% |
| Asparagine | N · Asn | 3 | 9.1% |
| Threonine | T · Thr | 3 | 9.1% |
| Alanine | A · Ala | 2 | 6.1% |
| Phenylalanine | F · Phe | 2 | 6.1% |
| Glycine | G · Gly | 2 | 6.1% |
| Serine | S · Ser | 2 | 6.1% |
| Glutamic acid | E · Glu | 1 | 3% |
| Histidine | H · His | 1 | 3% |
| Lysine | K · Lys | 1 | 3% |
| Methionine | M · Met | 1 | 3% |
| Glutamine | Q · Gln | 1 | 3% |
| Arginine | R · Arg | 1 | 3% |
| Tryptophan | W · Trp | 1 | 3% |
By side-chain class
Nonpolar, aliphatic
12 · 36.4%
A G I L M
Aromatic
3 · 9.1%
F W
Polar, uncharged
9 · 27.3%
N Q S T
Positively charged
3 · 9.1%
H K R
Negatively charged
6 · 18.2%
D E
Side-chain classes follow the standard grouping of the twenty proteinogenic amino acids. Composition is arithmetic over the published sequence and says nothing about how the molecule behaves.
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This is a reference entry. Sequence, residue count, molecular weight and atom count are published properties of the molecule, given for identification. Nothing on this page describes an application, benefit, dose, route or outcome, and nothing here should be read as an offer to supply or as guidance for use in a person or an animal. Materials sold by PepXtide are for laboratory research use only, are not for human or animal consumption, and have not been evaluated by the FDA.