Mitochondrial & Redox
Humanin
Mitochondrial-derived peptide
Reference entry · not stocked
4 more in Mitochondrial & RedoxIdentity
- Class
- Mitochondrial & Redox
- Molecular weight
- 2687 Da
- Residues
- 24
- Heavy atoms
- 187
- Reference slug
- humanin
These are published properties of the molecule, given for identification. Values we cannot confirm are omitted rather than estimated. What these terms mean.
What this compound is
Twenty-four residues encoded in mitochondrial DNA rather than the nuclear genome, like MOTS-c. A run of four leucines gives the middle of the chain a strongly hydrophobic face, so it is modelled as a helix.
Sequence
| 1 | MAPRGFSCLL LLTSEIDLPV KRRA |
|---|
- Three-letter code
- Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala
The one-letter code gives the amino-acid backbone. Terminal modifications, where a compound carries them, are accounted for in the molecular weight above but are not visible in the letters.
Residue composition
Counted directly from the sequence above. Humanin is built from 15 of the twenty standard amino acids across 24 positions.
By residue
| Residue | Code | Count | Share |
|---|---|---|---|
| Leucine | L · Leu | 5 | 20.8% |
| Arginine | R · Arg | 3 | 12.5% |
| Alanine | A · Ala | 2 | 8.3% |
| Proline | P · Pro | 2 | 8.3% |
| Serine | S · Ser | 2 | 8.3% |
| Cysteine | C · Cys | 1 | 4.2% |
| Aspartic acid | D · Asp | 1 | 4.2% |
| Glutamic acid | E · Glu | 1 | 4.2% |
| Phenylalanine | F · Phe | 1 | 4.2% |
| Glycine | G · Gly | 1 | 4.2% |
| Isoleucine | I · Ile | 1 | 4.2% |
| Lysine | K · Lys | 1 | 4.2% |
| Methionine | M · Met | 1 | 4.2% |
| Threonine | T · Thr | 1 | 4.2% |
| Valine | V · Val | 1 | 4.2% |
By side-chain class
Nonpolar, aliphatic
13 · 54.2%
A G I L M P V
Aromatic
1 · 4.2%
F
Polar, uncharged
4 · 16.7%
C S T
Positively charged
4 · 16.7%
K R
Negatively charged
2 · 8.3%
D E
Side-chain classes follow the standard grouping of the twenty proteinogenic amino acids. Composition is arithmetic over the published sequence and says nothing about how the molecule behaves.
Others in Mitochondrial & Redox
Glutathione
3 residues · 307 Da
A tripeptide of glutamate, cysteine and glycine. One honest caveat about this model: the first b…
In our catalogue
MOTS-c
16 residues · 2175 Da
A 16-residue peptide encoded in mitochondrial DNA rather than the nuclear genome. Investigated i…
In our catalogue
SS-31
4 residues · 640 Da
A four-residue peptide with an alternating aromatic-cationic motif that concentrates at the inne…
In our catalogue
This is a reference entry. Sequence, residue count, molecular weight and atom count are published properties of the molecule, given for identification. Nothing on this page describes an application, benefit, dose, route or outcome, and nothing here should be read as an offer to supply or as guidance for use in a person or an animal. Materials sold by PepXtide are for laboratory research use only, are not for human or animal consumption, and have not been evaluated by the FDA.