Mitochondrial & Redox

MOTS-c

Mitochondrial-derived peptide

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Identity

Class: Mitochondrial & Redox
Molecular weight: 2175 Da
Residues: 16
Heavy atoms: 153
Reference slug: mots-c

These are published properties of the molecule, given for identification. Values we cannot confirm are omitted rather than estimated. What these terms mean.

What this compound is

A 16-residue peptide encoded in mitochondrial DNA rather than the nuclear genome. Investigated in metabolic research around glucose handling and the exercise response. Modelled as an alpha helix.

Sequence

MOTS-c amino-acid sequence in one-letter code, numbered by residue position
1	MRWQEMGYIF YPRKLR

Three-letter code: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg

The one-letter code gives the amino-acid backbone. Terminal modifications, where a compound carries them, are accounted for in the molecular weight above but are not visible in the letters.

Residue composition

Counted directly from the sequence above. MOTS-c is built from 12 of the twenty standard amino acids across 16 positions.

By residue

Count of each amino acid in MOTS-c
Residue	Code	Count	Share
Arginine	R · Arg	3	18.8%
Methionine	M · Met	2	12.5%
Tyrosine	Y · Tyr	2	12.5%
Glutamic acid	E · Glu	1	6.3%
Phenylalanine	F · Phe	1	6.3%
Glycine	G · Gly	1	6.3%
Isoleucine	I · Ile	1	6.3%
Lysine	K · Lys	1	6.3%
Leucine	L · Leu	1	6.3%
Proline	P · Pro	1	6.3%
Glutamine	Q · Gln	1	6.3%
Tryptophan	W · Trp	1	6.3%

By side-chain class

Nonpolar, aliphatic
6 · 37.5%
G I L M P
Aromatic
4 · 25%
F W Y
Polar, uncharged
1 · 6.3%
Q
Positively charged
4 · 25%
K R
Negatively charged
1 · 6.3%
E

Side-chain classes follow the standard grouping of the twenty proteinogenic amino acids. Composition is arithmetic over the published sequence and says nothing about how the molecule behaves.

Primary literature

5 peer-reviewed papers indexed in PubMed that name this compound in the title. Each record was checked against the database for title, journal and year rather than written from memory.

Citations are listed so the underlying research can be read directly. They describe laboratory and preclinical work on the molecule. They are not evidence of a benefit, and nothing here is an application, dose, route or outcome.

Reference databases

PubChem

Compound record: Mots-c

Resolved from CAS 1627580-64-6

PubMed

Indexed literature

Live search for MOTS-c

ClinicalTrials.gov

Registered studies

Live search for MOTS-c

Links resolved against the live databases on 2026-08-29.

Glutathione

3 residues · 307 Da

A tripeptide of glutamate, cysteine and glycine. One honest caveat about this model: the first b…

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SS-31

4 residues · 640 Da

A four-residue peptide with an alternating aromatic-cationic motif that concentrates at the inne…

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Humanin

24 residues · 2687 Da

Twenty-four residues encoded in mitochondrial DNA rather than the nuclear genome, like MOTS-c. A…

Reference entry

All 4 compounds in Mitochondrial & Redox

This is a reference entry. Sequence, residue count, molecular weight and atom count are published properties of the molecule, given for identification. Nothing on this page describes an application, benefit, dose, route or outcome, and nothing here should be read as an offer to supply or as guidance for use in a person or an animal. Materials sold by PepXtide are for laboratory research use only, are not for human or animal consumption, and have not been evaluated by the FDA.