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Thymic & Immune

KPV

alpha-MSH (11-13)

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Identity

Class
Thymic & Immune
Molecular weight
342 Da
Residues
3
Heavy atoms
55
Reference slug
kpv

These are published properties of the molecule, given for identification. Values we cannot confirm are omitted rather than estimated. What these terms mean.

What this compound is

The C-terminal tripeptide of alpha-melanocyte-stimulating hormone. Small enough to show every hydrogen, and studied for anti-inflammatory signalling.

Sequence

Lys-Pro-Val

This sequence uses notation outside the standard twenty one-letter codes — a lowercase letter marks a D-amino acid, and other symbols mark modified or non-standard residues. It is reproduced exactly as published rather than normalised, and no residue composition is derived from it.

Primary literature

5 peer-reviewed papers indexed in PubMed that name this compound in the title. Each record was checked against the database for title, journal and year rather than written from memory.

  1. KPV attenuates adipogenesis and lipid metabolism through modulation of ROS-mediated AKT/mTORC1/PPARγ signaling

    Tissue Cell2026PMID 42585803

  2. Critical role of PepT1 in promoting colitis-associated cancer and therapeutic benefits of the anti-inflammatory PepT1-mediated tripeptide KPV in a murine model

    Cell Mol Gastroenterol Hepatol2016PMID 27458604

  3. Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease

    Inflamm Bowel Dis2008PMID 18092346

  4. Lysine-proline-valine peptide attenuates hepatic lipid accumulation through ROS-dependent regulation of the PPARγ pathway in HepG2 cells

    Cytotechnology2026PMID 42064835

  5. Lysine-Proline-Valine peptide mitigates fine dust-induced keratinocyte apoptosis and inflammation by regulating oxidative stress and modulating the MAPK/NF-κB pathway

    Tissue Cell2025PMID 40073467

Citations are listed so the underlying research can be read directly. They describe laboratory and preclinical work on the molecule. They are not evidence of a benefit, and nothing here is an application, dose, route or outcome.

Reference databases

PubChem

Compound record: Msh (11-13)

Resolved from CAS 67727-97-3

PubMed

Indexed literature

Live search for KPV

Links resolved against the live databases on 2026-08-29.

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All 11 compounds in Thymic & Immune

This is a reference entry. Sequence, residue count, molecular weight and atom count are published properties of the molecule, given for identification. Nothing on this page describes an application, benefit, dose, route or outcome, and nothing here should be read as an offer to supply or as guidance for use in a person or an animal. Materials sold by PepXtide are for laboratory research use only, are not for human or animal consumption, and have not been evaluated by the FDA.