Thymic & Immune
LL-37
Human cathelicidin, all 37 residues
Reference entry · not stocked
11 more in Thymic & ImmuneIdentity
- Class
- Thymic & Immune
- Molecular weight
- 4493 Da
- Residues
- 37
- Heavy atoms
- 318
- Reference slug
- ll-37
These are published properties of the molecule, given for identification. Values we cannot confirm are omitted rather than estimated. What these terms mean.
What this compound is
The complete human cathelicidin. Strongly cationic, with five lysines and five arginines, which is what lets it associate with membranes. One of the largest structures here, so it is drawn without hydrogens to stay readable.
Sequence
| 1 | LLGDFFRKSK EKIGKEFKRI VQRIKDFLRN LVPRTES |
|---|
- Three-letter code
- Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser
The one-letter code gives the amino-acid backbone. Terminal modifications, where a compound carries them, are accounted for in the molecular weight above but are not visible in the letters.
Residue composition
Counted directly from the sequence above. LL-37 is built from 14 of the twenty standard amino acids across 37 positions.
By residue
| Residue | Code | Count | Share |
|---|---|---|---|
| Lysine | K · Lys | 6 | 16.2% |
| Arginine | R · Arg | 5 | 13.5% |
| Phenylalanine | F · Phe | 4 | 10.8% |
| Leucine | L · Leu | 4 | 10.8% |
| Glutamic acid | E · Glu | 3 | 8.1% |
| Isoleucine | I · Ile | 3 | 8.1% |
| Aspartic acid | D · Asp | 2 | 5.4% |
| Glycine | G · Gly | 2 | 5.4% |
| Serine | S · Ser | 2 | 5.4% |
| Valine | V · Val | 2 | 5.4% |
| Asparagine | N · Asn | 1 | 2.7% |
| Proline | P · Pro | 1 | 2.7% |
| Glutamine | Q · Gln | 1 | 2.7% |
| Threonine | T · Thr | 1 | 2.7% |
By side-chain class
Nonpolar, aliphatic
12 · 32.4%
G I L P V
Aromatic
4 · 10.8%
F
Polar, uncharged
5 · 13.5%
N Q S T
Positively charged
11 · 29.7%
K R
Negatively charged
5 · 13.5%
D E
Side-chain classes follow the standard grouping of the twenty proteinogenic amino acids. Composition is arithmetic over the published sequence and says nothing about how the molecule behaves.
Others in Thymic & Immune
KPV
3 residues · 342 Da
The C-terminal tripeptide of alpha-melanocyte-stimulating hormone. Small enough to show every hy…
In our catalogue
Thymosin alpha-1
28 residues · 3108 Da
Twenty-eight residues with an acetyl group capping the N-terminus, which is drawn here. Striking…
In our catalogue
Peptide T
8 residues · 858 Da
Eight residues, four of them threonine, which is unusual enough to be worth seeing. Named for th…
Reference entry
Rigin
4 residues · 457 Da
Four residues from immunoglobulin G, structurally analogous to tuftsin. Small enough to show eve…
Reference entry
Splenopentin
5 residues · 694 Da
Five residues from splenin. One residue different from thymopentin, which is also in this librar…
Reference entry
Thymocartin
4 residues · 517 Da
Four residues, thymopentin minus its terminal tyrosine. Both are here, so the difference is visi…
Reference entry
This is a reference entry. Sequence, residue count, molecular weight and atom count are published properties of the molecule, given for identification. Nothing on this page describes an application, benefit, dose, route or outcome, and nothing here should be read as an offer to supply or as guidance for use in a person or an animal. Materials sold by PepXtide are for laboratory research use only, are not for human or animal consumption, and have not been evaluated by the FDA.