Thymic & Immune
Thymosin alpha-1
Acetylated 28-residue thymic peptide
Identity
- Class
- Thymic & Immune
- Molecular weight
- 3108 Da
- Residues
- 28
- Heavy atoms
- 217
- Reference slug
- thymosin-alpha-1
These are published properties of the molecule, given for identification. Values we cannot confirm are omitted rather than estimated. What these terms mean.
What this compound is
Twenty-eight residues with an acetyl group capping the N-terminus, which is drawn here. Strikingly acidic: eight glutamates and four aspartates out of twenty-eight.
Sequence
| 1 | SDAAVDTSSE ITTKDLKEKK EVVEEAEN |
|---|
- Three-letter code
- Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn
The one-letter code gives the amino-acid backbone. Terminal modifications, where a compound carries them, are accounted for in the molecular weight above but are not visible in the letters.
Residue composition
Counted directly from the sequence above. Thymosin alpha-1 is built from 10 of the twenty standard amino acids across 28 positions.
By residue
| Residue | Code | Count | Share |
|---|---|---|---|
| Glutamic acid | E · Glu | 6 | 21.4% |
| Lysine | K · Lys | 4 | 14.3% |
| Alanine | A · Ala | 3 | 10.7% |
| Aspartic acid | D · Asp | 3 | 10.7% |
| Serine | S · Ser | 3 | 10.7% |
| Threonine | T · Thr | 3 | 10.7% |
| Valine | V · Val | 3 | 10.7% |
| Isoleucine | I · Ile | 1 | 3.6% |
| Leucine | L · Leu | 1 | 3.6% |
| Asparagine | N · Asn | 1 | 3.6% |
By side-chain class
Nonpolar, aliphatic
8 · 28.6%
A I L V
Polar, uncharged
7 · 25%
N S T
Positively charged
4 · 14.3%
K
Negatively charged
9 · 32.1%
D E
Side-chain classes follow the standard grouping of the twenty proteinogenic amino acids. Composition is arithmetic over the published sequence and says nothing about how the molecule behaves.
Primary literature
3 peer-reviewed papers indexed in PubMed that name this compound in the title. Each record was checked against the database for title, journal and year rather than written from memory.
Serum thymosin alpha 1 levels in normal and pathological conditions
Expert Opin Biol Ther2018PMID 30063864
NMR structure of human thymosin alpha-1
Biochem Biophys Res Commun2011PMID 22115779
The conformation of peptide thymosin alpha 1 in solution and in a membrane-like environment by circular dichroism and NMR spectroscopy. A possible model for its interaction with the lymphocyte membrane
Peptides1998PMID 9880079
Citations are listed so the underlying research can be read directly. They describe laboratory and preclinical work on the molecule. They are not evidence of a benefit, and nothing here is an application, dose, route or outcome.
Reference databases
PubChem
Compound record: Thymalfasin
Resolved from the compound name
PubMed
Indexed literature
Live search for Thymosin alpha-1
ClinicalTrials.gov
Registered studies
Live search for Thymosin alpha-1
Links resolved against the live databases on 2026-08-29.
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Reference entry
This is a reference entry. Sequence, residue count, molecular weight and atom count are published properties of the molecule, given for identification. Nothing on this page describes an application, benefit, dose, route or outcome, and nothing here should be read as an offer to supply or as guidance for use in a person or an animal. Materials sold by PepXtide are for laboratory research use only, are not for human or animal consumption, and have not been evaluated by the FDA.